Work

Orchestrating tumor-immune epigenetics via SERT–H3Q5ser axis

Year: 2025

Type: article

Abstract: The serotonin transporter (SERT) and histone H3 serotonylation (H3Q5ser) integrate extracellular neurotransmitter signals to chromatin regulation in cancer. Here, we discuss how the SERT-H3Q5ser axis shapes tumor immunity and epigenetic plasticity, and highlight emerging strategies to therapeutically target this neuro-epigenetic interface.

Source: Trends in cancer

DOI: 10.1016/j.trecan.2025.11.004

Author: Canhui Cao

Institutions: Tongji Hospital, Huazhong University of Science and Technology

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030