Immunoglobulin G4-Related Disease Masquerading as Crohn Disease, Managed by Intestinal Ultrasound: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: We present the case of a 36-year-old man initially diagnosed with Crohn disease who was nonresponsive to numerous advanced therapies. Further evaluation revealed diffuse lymphadenopathy, severe enterocolitis, and significantly elevated immunoglobulin G4 levels. Staining of colonic biopsies confirmed IgG4-related enterocolitis. Treatment with rituximab therapy and dose adjustment guided by clinical symptoms, stool calprotectin, and intestinal ultrasound resulted in symptomatic, endoscopic, histologic, and transmural healing.
Institutions: University of Chicago, University of Chicago Medical Center
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416929218