Year: 2025
Type: article
Abstract: Neurodegenerative diseases such as Alzheimer’s disease are marked by protein misfolding and persistent neuroinflammation leading to synaptic damage. Nanomaterial-based interventions have emerged as a promising approach to address these multifaceted pathologies by simultaneously inhibiting toxic protein aggregation and modulating glial overactivation. Negative-surface gold nanoparticles, carbon dots, and other engineered constructs exhibit strong adsorption capabilities that limit amyloid-β or tau fibrillization, while photothermal strategies using graphene or gold nanorods destabilize established aggregates. Meanwhile, functionalized nanocarriers deliver targeted anti-inflammatory agents across the blood–brain barrier through receptor-mediated transport or biomimetic cell membrane coatings, attenuating proinflammatory cytokines and promoting autophagic clearance. In vitro and in vivo models demonstrate synergistic outcomes, with reduced plaque burden, improved neuronal survival, and enhanced cognitive measures. Despite challenges in large-scale synthesis and long-term safety, evolving nanoplatforms highlight an integrative, customizable framework for effectively tackling the harmful feedback loop of protein misfolding, neuroinflammation, and disease progression.
Source: 动物学研究
Authors: Wang Yu-He, 四川大学华西第二医院妇产科, 出生缺陷与相关妇儿疾病教育部重点实验室, 四川 成都 610041, 中国, Lang Xiao-Ling, Qing Xiu-Li, 四川大学华西第二医院运营管理办公室, 出生缺陷与相关妇儿疾病教育部重点实验室, 四川 成都 610041, 中国
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416930073