Work

Light-driven synthesis of 3-(hetero)aryl/alkyl-1-indanone derivatives from indan-1,3-diones and boronic acids via N-tosylhydrazones

Year: 2025

Type: article

Abstract: An efficient methodology has been developed for synthesizing 3-(hetero)aryl/alkyl-indan-1-ones, which are highly valued scaffolds in chemistry. This method allows the mono(hetero)arylation/alkylation of indane-1,3-diones with (hetero)aryl/alkyl boronic acids under light-induced reaction conditions with the aid of K3PO4. A three-component approach also achieved the one-pot synthesis of 3-aryl/alkyl-indan-1-ones in good yields. UV absorption studies observed light-induced cleavage of the N–S bond of N-tosylhydrazone. We have also demonstrated the synthetic utility of C3-substituted aryl/alkyl-indan-1-ones and synthesized a biologically active molecule.

Source: Tetrahedron Chem

DOI: 10.1016/j.tchem.2025.100150

Authors: Mohammad Junaid, Pokhriyal Yamini, Dongari Yadagiri

Institution: Indian Institute of Technology Roorkee

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,660