Work

Dearomative Higher‐Order Cycloaddition for the Construction of Dihydropyrimidin‐4(1 H )‐One Scaffold Employing N ‐Heterocyclic Carbene Catalysis

Year: 2025

Type: article

Abstract: In this article, we demonstrate that dearomative higher‐order cycloaddition constitutes a useful method for the construction of biologically relevant dihydropyrimidin‐4(1 H )‐one scaffold. The reaction utilizes indole‐7‐carbaldehydes acting as higherene precursors that under N ‐heterocyclic carbene (NHC) catalysis, lead to the generation of NHC‐bound aza‐ o ‐quinodimethanes. Their cycloaddition with cyclic trifluoromethyl ketimines, acting as hetero‐higherenophiles, proceeds in an asymmetric fashion opening access to high molecular complexity in a single step.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70197

Authors: Adam Cieśliński, Artur Przydacz, Anna Skrzyńska, Łukasz Albrecht

Institution: Lodz University of Technology

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funders: Narodowym Centrum Nauki, Politechnika Lódzka, Wydział Chemiczny, Politechnika Łódzka