Short‐Term Thrombosis Following Coronary Stent Implantation in a Patient With Myocardial Infarction and COVID‐19 Infection: A Case Report and Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: In-stent thrombosis is a rare but devastating complication following percutaneous coronary intervention, and its risk may be significantly heightened by the pro-inflammatory and hypercoagulable state induced by COVID-19 infection. This case report details a 62-year-old male with acute non-ST-elevation myocardial infarction who underwent successful drug-eluting stent implantation, only to develop catastrophic in-stent thrombosis and cardiac rupture within one hour post-procedure, concurrent with a mild COVID-19 infection. Despite emergency thrombectomy and surgical intervention, the patient succumbed to refractory cardiogenic shock. This case, alongside a review of similar published reports, underscores the alarmingly rapid onset of stent thrombosis in COVID-19 patients and suggests that the viral infection acts as a potent precipitating factor. The pathophysiology likely involves immune-mediated endothelial injury, platelet hyperreactivity, and a systemic inflammatory cascade. The discussion highlights the critical need for heightened vigilance, consideration of intensified peri-procedural antithrombotic strategies (such as glycoprotein IIb/IIIa inhibitors), and the potential role of intravascular imaging in this high-risk patient population. This report concludes that managing acute coronary syndrome in the context of COVID-19 requires a personalized and aggressive approach to mitigate the elevated threat of early stent thrombosis.
DOI: 10.1002/ccd.70398
Authors: Fangfang Gu, Zhenfeng Chen, Yuliang Lu, Shijian Chen
Institutions: Zhejiang Chinese Medical University, Huzhou Central Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4416935413