Work

Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02244

Authors: Wentao Zhu, Jian Chen, Wenqian Zhang, Yinmiao Wang, Fang Xu, Jiyan Pang

Institutions: Sun Yat-sen University, Jinan University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province

Awards: G3256866440, G3593726445

OpenAlex ID: W4416937746

FWCI: 1.044

Cites: 27

Cited by: 4

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