Work

Access to allyl- gem -difluorides via allylation and Cope rearrangement

Year: 2025

Type: article

Abstract: We report a deborylative allylation/Cope rearrangement that enables efficient access to allyl gem -difluorides bearing ( E )-vinyl boronic esters. Broad scope and synthetic versatility are demonstrated, providing valuable fluorinated building blocks.

Source: Chemical Science

DOI: 10.1039/d5sc08340k

Authors: Haeun Kim†, Seungcheol Han†, Yunhui Jang, Yujin Jung, Seung Hwan Cho

Institution: Pohang University of Science and Technology

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond