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Heterologous biosynthetic crosstalk with the native mansouramycin cluster in Streptomyces albus Del14 reveals unexpected metabolites

Year: 2025

Type: article

Abstract: Del14, triggered by SARP regulators present on the introduced BGC. These findings highlight the evolutionary significance of BGC interactions and underscore their potential as a powerful tool for discovering novel natural products, providing insights that could inform innovative strategies in biosynthetic engineering and the guided evolution of new bioactive compounds.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00235d

Authors: Marc Stierhof, Liliya Horbal, Patrick Oberhäuser, Anja Palusczak, Peyton Cox, Maria Lopatniuk, Christopher Ruf, Josef Zapp, Andriy Luzhetskyy

Institutions: Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Universität des Saarlandes

Awards: Ein neuartiger Biosyntheseweg zur Produktion von Isochinolinen in Streptomyces albus, G8397553588

OpenAlex ID: W4416938951

FWCI: 0.483

Cites: 39

Cited by: 1

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