Work

Research progress on the effect of intestinal microbiota on liver injury caused by particulate matter exposure and the intervention mechanism of lactic acid bacteria

Year: 2025

Type: article

Abstract: Food processing activities emit a number of air pollutants, including fine particulate matter (PM), which has emerged as a significant environmental risk factor for human health. In recent years, increased emphasis has been paid to the detrimental health impacts of air pollution. PM, being a primary component of air pollution, has historically been seen as predominantly damaging to the respiratory system. Still, with the deepening of the research, PM enters the intestinal tract through the internal circulation, causing intestinal damage and gut microbiome (GM) disorders, which affects the function of GM, and through the portal or intestinal barriers, it brings a harmful effect on the liver of the human body. Therefore, this paper summarizes the research progress in recent years through the intestinal flora, the mechanism of PM-induced liver injury and the intervention mechanism of lactobacilli (LAB), and explores the effects of PM on the gut-liver axis, and the intervention role of lactobacilli (LAB) through those mechanisms, to provide scientific new ideas for the study of LAB intervention in PM-induced GM disorders leading to liver injury.

Source: Food Science and Human Wellness

DOI: 10.26599/fshw.2025.9250851

Authors: Shiyao Jiang, Longfei Guo, Junling Wang

Institutions: Lanzhou University, Gansu Provincial Hospital

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities