Work

Analysis of Carbapenem-Resistant Enterobacterales Resistance in a Hospital in Kunming Over the Past Two Years

Year: 2025

Type: article

Abstract: Objective: To examine the species distribution, clinical prevalence, antimicrobial profiles, and carbapenemase phenotypes of carbapenem-resistant Enterobacterales (CRE) isolated from a tertiary hospital over the past two years, thereby providing a reference for clinical anti-infection strategies and hospital infection control measures. Methods: A retrospective analysis was performed to examine the distribution of CRE strains isolated from inpatients at a tertiary hospital between 2023 and 2024, their resistance profiles to commonly used antibiotics and carbapenemase phenotypes. Results: . These CRE strains were mainly isolated from departments such as geriatrics, intensive care units (ICU), and respiratory medicine. Among the 239 CRE isolates, there was a notably high resistance rate to cephalosporins, enzyme inhibitor combinations, aminoglycosides, and quinolones, exceeding 85%, with carbapenems exhibiting a resistance rate of over 90%. Conversely, the resistance rates to tigecycline, ceftazidime/avibactam, and polymyxin B were 1.26%, 24.24%, and 5.43%, respectively. The majority of strains (74.06%) produced class A serine carbapenemases, specifically the KPC type. Conclusion: The CRE isolation and resistance rates in this hospital are similar to international trends, both showing an upward trend, and comparison with domestic data reveals significant regional differences. CRE infections are difficult to treat and have a high mortality rate. Therefore, to meet the needs of Infection Prevention and Control, it is necessary to strengthen the monitoring of CRE resistance in this institution, contributing to the prevention, control, and clinical management capabilities for infections.

Source: Infection and Drug Resistance

DOI: 10.2147/idr.s552889

Authors: Zhineng Xu, Lingnan Xu, Dehua Liu

Institutions: Kunming University, The First Hospital of Kunming

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836