Work

Comparison of the Effects of Tocilizumab and High-dose Steroid Treatment on Treatment Response and Mortality in Hospitalized COVID-19 Pneumonia Patients with Cytokine Storm

Year: 2025

Type: article

Abstract: Objective: Cytokine storm associated with coronavirus disease-2019 (COVID-19) is a major contributor to COVID-19-related mortality.This study aimed to evaluate and compare the clinical and laboratory effects, as well as mortality outcomes, of high-dose steroid therapy versus tocilizumab treatment in patients experiencing this hyperinflammatory state.Method: This retrospective, single-center cohort study analyzed the records of 200 patients who were hospitalized at University of Health Sciences Turkey, Gazi Yaşargil Training and Research Hospital with COVID-19 pneumonia and diagnosed with a cytokine storm between February 1 and September 30, 2021.Eligibility criteria required that Amaç: Koronavirüs hastalığı-2019 (COVID-19) ile ilişkili sitokin fırtınası sendromu, hastalıkla ilişkili mortalitenin önemli bir nedenidir.Bu çalışmada; sitokin fırtınası gelişen hastalarda; yüksek doz steroidler ile tosilizumabın klinik ve laboratuvar sonuçlar ile mortalite üzerindeki etkilerini karşılaştırmayı amaçladık.

Source: Bagcilar Medical Bulletin

DOI: 10.4274/bmb.galenos.2025.30602