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A novel inhaled anesthesia technique for concurrent direct laryngoscopy in rats

Year: 2025

Type: article

Abstract: The current anesthetic standard for laryngoscopy in rats utilizes injectable intraperitoneal anesthesia. Injectable anesthesia is suboptimal for short procedures due to variability in anesthesia duration and anesthetic side effects. Conversely, inhalational gas anesthesia offers precise titration with a rapid onset and offset. However, its use during laryngoscopy has not been documented due to existing administration techniques obstructing direct visualization of the larynx. The technique described here allows real-time visualization of the rat larynx with concurrent administration of inhaled anesthetic gas. This method is particularly well-suited for recurrent laryngeal nerve or vocal fold pathology studies, where repeat visualization of the larynx is necessary.

Source: Animal Models and Experimental Medicine

DOI: 10.1002/ame2.70116

Authors: Corinne Negvesky, Amin Mirzaaghasi, Eric M. Smith, Ashley E. Kita

Institution: University of California, Los Angeles

Language: English

Topic: Veterinary Pharmacology and Anesthesia

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000