Formylated Bile Acid–Steroid Conjugates: Synthesis, Antifungal Properties, and In Silico Studies
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Fungal infections caused by Alternaria alternata, Fusarium culmorum (F. culmorum), and Botrytis cinerea (B. cinerea) pose significant risks to agriculture and human health. The emergence of fungicide resistance underscores the need for new antifungal agents. Bile acid–steroid conjugates, synthesized via “click chemistry”, offer a promising solution due to their stability and biological activity. In this study, bile acid derivatives linked by 1,2,3-triazole rings were synthesized and evaluated for antifungal activity. Spectroscopic analysis confirmed successful conjugation, and molecular docking studies identified interactions with fungal targets. Biological assays revealed potent antifungal effects, especially against F. culmorum and B. cinerea, with compounds ( 23 ) and ( 24 ) showing the strongest activity. These findings highlight the potential of bile acid derivatives as novel antifungal agents, and further optimization could enhance their efficacy and selectivity for therapeutic applications.
Source: ACS Omega
Language: English
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W4416947433