Work

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity (Adv. Funct. Mater. 49/2025)

Year: 2025

Type: article

Abstract: Programmable Nanomaterials This cover illustrates the internal architecture of a DNA-crosslinked cell-culture matrix (DyNAtrix). Dynamically switchable DNA crosslinks regulate mechanical interactions between living cells and their three-dimensional microenvironment. Leveraging DNA nanotechnology, DyNAtrix allows researchers to study cellular mechanotransduction and to actively guide the development of cells and organoids in a Petri dish (Design contribution: Yu-Hsuan Peng). More information can be found in the Research Article by Elisha Krieg and co-workers (10.1002/adfm.202513028).

Source: Advanced Functional Materials

DOI: 10.1002/adfm.72719

Authors: Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg

Institutions: Leibniz Institute of Polymer Research, Center for Regenerative Therapies Dresden, Physics of Life, Technische Universität Dresden, Biotechnologisches Zentrum

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4416948088

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