Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis
Year: 2025
Type: article
Abstract: , Hyp significantly reduced H2O2‑induced oxidative stress in BMSCs and promoted their osteogenic differentiation. Mechanistically, Hyp was found to activate the PI3K/AKT signaling pathway, suggesting its notable role in mediating the antioxidant and osteoinductive effects of Hyp. Summarily, Hyp may effectively alleviate OVX‑induced OP in mice, potentially by mitigating oxidative stress and promoting osteogenesis via activation of the PI3K/AKT signaling pathway. These findings provide novel insights into the therapeutic mechanism of Hyp and support its potential as a candidate agent for OP treatment.
Source: Molecular Medicine Reports
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4416949489
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