Work

Adenovirus E1A protein sensitizes chemotherapy-resistant tumors to cisplatin

Year: 2025

Type: article

Abstract: Cisplatin resistance remains a critical obstacle in surgical oncology, with treatment failure exceeding 60% in recurrent solid tumors. The adenovirus type 5 early region 1A (E1A) protein demonstrates remarkable chemosensitization through p53-dependent and p53-independent pathways, achieving a 10-fold enhancement in cisplatin sensitivity in resistant cell lines. Clinical trials combining E1A-expressing oncolytic adenoviruses with cisplatin show response rates of 63% compared to 30-40% for chemotherapy alone. E1A restores apoptotic responses through p19ARF/p53 signaling, nuclear factor-kappaB inhibition, and CtBP corepressor interactions. Integration with surgical cytoreduction offers promise for neoadjuvant tumor downstaging and adjuvant micrometastatic elimination. Despite immunogenicity challenges, E1A-based viral therapeutics represent a mechanistically validated approach warranting inclusion in multimodal treatment strategies for chemotherapy-resistant cancers.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000004440

Authors: Muhammad Shahid Mehmood, Muhammad Ismail, Naseeb Danaf

Institutions: University of Agriculture Faisalabad, Lebanese University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850