ERRATUM: Acute Toxicity Studies of Nutmeg Pulp Ethanol Extract (Myristica fragrans Houtt.) in Balb/c Mice
Year: 2025
Type: erratum
Abstract: Myristicin is a chemical frequently present in nutmeg (Myristica fragrans Houtt.). Excessive consumption might result in Toxicity and hallucinogenic effects. The compound is found throughout the nutmeg fruit, with the most significant quantity found in the pulp, measuring 36.05%. This research seeks to ascertain the acute toxicity of nutmeg pulp ethanol extract (Myristica fragrans Houtt.) in Balb-C mice (Mus musculus). A total of 20 female mice were categorized into four groups: the control group, NPE 750 mg, NPE 1500 mg, and NPE 2500 mg. The test preparation was administered orally with a single dose at the study's commencement, and toxicological symptoms were observed over 14 days. The findings indicated that the ethanol extract of nutmeg pulp ( Myristica fragrans Houtt.) at doses of 750 mg/kgBW, 1500 mg/kgBW, and 2500 mg/kgBW exhibited signs of toxicity, including grooming, tremors, anorexia, ptosis, and fluctuations in body weight, with an LD50 value of 2964.83 mg/kgBW. Histopathological examination of the liver tissue revealed increased hepatocyte necrosis at the highest dose of 2500 mg/kgBW. In conclusion, the ethanol extract of nutmeg pulp exhibits toxic potential when administered at doses exceeding 750 mg/kgBW. Moreover, it affects the liver when consumed at doses over 2500 mg/kgBW
Authors: Amran Nur, Ermalyanti Fiskia, Muhammad F. R. H. Yusuf, Muhammad Z. A. Disi, Yusri Sapsuha, Muhammad S.A Sibadu, Hasyrul Hamzah
Institutions: Khairun University, Universitas Muhammadiyah Kalimantan Timur
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4416953905
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