Work

Synthesis and QSAR Studies of Claramine Derivatives, a New Class of Broad-Spectrum Antimicrobial Agents

Year: 2025

Type: article

Abstract: The development of new antibiotics has been recognized for over two decades as a major challenge in combating multidrug-resistant bacteria. Herein, we report the synthesis and QSAR studies of claramine derivatives, a new class of broad-spectrum antimicrobial agents active against both susceptible and resistant Gram-positive and Gram-negative strains. The observed antimicrobial activities were rationalized based on key topological parameters of the derivatives, while cytotoxicity was interpreted by correlating half maximal inhibitory concentration (IC50) values with QSAR models. Owing to the low cytotoxicity observed for several analogues, this molecular class represents a promising alternative for the development of novel agents to counteract multidrug resistance.

Source: Molecules

DOI: 10.3390/molecules30234614

Authors: Marine Blanchet, Carole Di Giorgio, Jean Michel Brunel

Institutions: Inserm, Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut Méditerranéen de Biodiversité et d'Ecologie Marine et Continentale, Institut de Recherche pour le Développement

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258