Work

Interferon-stimulated gene 15 small interfering RNA-loaded polarized mesoporous silica nanocarriers remodel the immune microenvironment to ameliorate post-myocardial infarction heart failure

Year: 2025

Type: article

Abstract: . In the post-MI HF rat model, treatment with pMSNC@ISG15 siRNA led to significant improvements in cardiac function, reduced fibrosis, and increased M2-type macrophages, highlighting its potential as a nanomedicine-based therapeutic strategy for HF. The study provides valuable insights into the use of nanocarriers for targeted gene therapy in cardiac diseases.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2025.102631

Authors: Jianfen Shen, Zhongbao Fan, Lina Ren, Yanbin Cheng, Chunwei Wu

Institutions: First Hospital of China Medical University, China Medical University, Liaoning Provincial People's Hospital

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400