Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy
Year: 2025
Type: article
Abstract: This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy, such as Cerebrolysin, is likely to further improve patient outcomes. Beyond its established neurorecovery benefits, recent data indicate that Cerebrolysin also offers protection to the neurovascular unit and the blood-brain barrier. This paper introduces the CErebrolysin in RECanalization And Perfusion (CERECAP) program, a collaborative initiative of independent academic investigations exploring the favorable trends of Cerebrolysin in reperfusion. The CERECAP program has generated compelling data demonstrating Cerebrolysin's alignment with current AIS reperfusion therapy concepts, particularly its role in early intervention targeting multiple pathways. We review these studies and discuss the critical need to clearly define the patient population that benefit most from adjunctive Cerebrolysin therapy in AIS.
Authors: Marc Ribó, Jacek Staszewski, Steven R. Zeiler, Sławomir Michalak, Ahmed El Bassiouny, Fernando Gongora-Rivera, Zdravka Poljakovic, Dina R Khasanova, Mikhail N Kalinin, Aurauma Chutinet, Roni Eichel, Klaudyna Kojder, Marissa Ong, Marina Roje Bedeković, Chien-Hung Chang, Minwoo Lee, Peter Quitasol, Alexander Tsiskaridse, Natan M Bornstein
Institutions: Vall d'Hebron Hospital Universitari, Johns Hopkins University, Ain Shams University, Hospital Universitario Dr José Eleuterio Gonzalez, Kazan State Medical University, Chulalongkorn University, Shaare Zedek Medical Center, Bikur Cholim Hospital, Pomeranian Medical University, East Avenue Medical Center, University Hospital Centre Zagreb, Sisters of Charity Hospital, Linkou Chang Gung Memorial Hospital, Hallym University Sacred Heart Hospital, Baguio General Hospital and Medical Center, Tbilisi State University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,170
OpenAlex ID: W4416957420