Improved cross-protection and immunity against influenza A virus in mice using a novel mRNA vaccine with optimized design of RNA sequence
Year: 2025
Type: article
Abstract: T cell responses, and more effective protection than those of HNH-ORI, owing to their lower minimum free energy and higher codon adaptation index. These results reveal that the LPP-HNH mRNA vaccine encoding conserved antigens with optimized sequences is a promising strategy for the development of universal influenza vaccines.
Authors: Tangqi Wang, Ruiwen Han, Zhanyihao Hao, Xueting Cheng, Jia Li, Chengcheng Zhai, Junjia Guo, Donghong Wang, Yao Deng, Liang Zhang, Wenjie Tan
Institutions: Chinese Center For Disease Control and Prevention, Wenzhou Medical University, National Institute for Viral Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Chinese Academy of Sciences, Hangzhou Institute of Medicine, Chinese Academy of Sciences
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
OpenAlex ID: W4416958427