Work

Successful Substrate-Guided Ablation of Ventricular Tachycardia Storm in Acute Heart Failure Without Mechanical Circulatory Support

Year: 2025

Type: article

Abstract: BACKGROUND: Ventricular tachycardia (VT) storm in advanced systolic heart failure carries high morbidity and mortality. Ablation is often performed with advanced imaging and mechanical circulatory support, which may not be available in resource-limited settings. CASE SUMMARY: A 62-year-old man with ischemic cardiomyopathy (left ventricular ejection fraction: 25% to 30%) presented with recurrent monomorphic VT refractory to antiarrhythmic therapy, complicated by hemodynamic instability and multiorgan dysfunction. Mechanical circulatory support was not feasible. Substrate-guided mapping using voltage, late potentials, local abnormal ventricular activity, isochronal late activation mapping, and decrement-evoked potential mapping localized a critical isthmus in the basal posterior left ventricle. Ablation terminated VT and rendered it noninducible under monitored anesthesia care with norepinephrine and low-dose dobutamine. CONCLUSION: Functional substrate mapping with limited intra-VT mapping and tailored anesthesia enabled procedural stability and successful VT ablation. TAKE-HOME MESSAGE: Substrate-guided mapping with individualized hemodynamic support can achieve safe, effective VT ablation in resource-limited settings.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.106214

Authors: Le Uyen Phuong Tran, Quoc Hoang Nguyen, Cao Dat Tran, Ngoc Dung Kieu, Chau N. Vo

Institutions: Cho Ray Hospital, Medical University of South Carolina

Language: English

Topic: Cardiac Arrhythmias and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850