Work

The future of osteoarthritis treatment: exploring the potential of exosomes from adipose tissue-derived stem cells

Year: 2025

Type: article

Abstract: Aims: This review examines the therapeutic potential of adipose tissue-derived stem cell (ADSC) exosomes for osteoarthritis (OA), focusing on their anti-inflammatory and cartilage regeneration properties. Methods: A PubMed search (2012 to 2024) was conducted using keywords related to ADSCs, exosomes, and OA. Inclusion criteria focused on studies investigating ADSCs and ADSC-exosomes characteristics, animal OA models, and human OA patients. Exclusion criteria included case reports, case series, and conference abstracts. Results: ADSCs are an abundant stem cell source with low immunogenicity. ADSC-exosomes exhibit anti-inflammatory effects and promote cartilage regeneration via miRNA transport. Preclinical studies demonstrate inhibition of synovial thickening, cartilage destruction, and macrophage activity. Clinical trials suggest that intra-articular ADSCs are safe and effective, with higher doses improving pain relief and cartilage regeneration. Conclusion: ADSC-exosomes are a promising cell-free therapy for OA, with reduced immune rejection and tumorigenicity compared to ADSC transplantation. Standardizing exosome isolation and production remains a challenge. Further research is needed to confirm long-term safety and efficacy in humans.

Source: Bone and Joint Research

DOI: 10.1302/2046-3758.1412.bjr-2025-0117.r1

Authors: Pin-Han Huang, Sung-Yen Lin, Chung-Hwan Chen, Yin-Chih Fu, Tien-Ching Lee

Institutions: Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,594