Work

Association of serotonin and ergot alkaloids on tissue partitioning and contractile response of bovine blood vessels

Year: 2025

Type: article

Abstract: M). However, the presence of 5-HT did not affect (P = 0.368) tissue ergovaline partitioning. When 5-HT was not added, ergovaline reduced (P < 0.05) the 5-HT concentration in the blood vessel. Pre-incubation with ergovaline reduced contractile response by about 95 % (P < 0.05) and 5-HT did not change its effect. Ergot alkaloid partitioning is associated with reduced tissue 5-HT levels and blood vessel contractility.

Source: Current Research in Toxicology

DOI: 10.1016/j.crtox.2025.100272

Authors: Eriton E.L. Valente, David L. Harmon, John May, Huihua Ji, Ronald J. Trotta, James L. Klotz

Institutions: Universidade Estadual do Oeste do Paraná, University of Kentucky, Agricultural Research Service

Language: English

Topic: Alkaloids: synthesis and pharmacology

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,440