Work

Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK biobank

Year: 2025

Type: article

Abstract: , which are involved in immune regulation. ME/CFS mGWAS summary statistics were decomposed to uncover shared genetic-metabolic patterns, where enrichment analysis highlighted pathways in lipid metabolism, neurotransmitter transport, and inflammation. These findings provide a genetic and molecular rationale for patient heterogeneity and suggest a polygenic predisposition in which many small-effect variants may jointly perturb metabolic mechanisms.

Source: iScience

DOI: 10.1016/j.isci.2025.114316

Authors: Katherine Huang, Muhammad Muneeb, Natalie Thomas, Elena K. Schneider-Futschik, Paul R. Gooley, David B. Ascher, Christopher W. Armstrong

Institutions: The University of Melbourne, The University of Queensland, Baker Heart and Diabetes Institute

Language: English

Topic: Fibromyalgia and Chronic Fatigue Syndrome Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Judith Jane Mason and Harold Stannett Williams Memorial Foundation, University of Melbourne, State Government of Victoria, National Health and Medical Research Council

Awards: Using protein structure to combat antimicrobial resistance, Exposure to Cystic Fibrosis Modulators During Pregnancy to Mitigate Pathology Development in Offspring.

OpenAlex ID: W4416971843

FWCI: 1.271

Cites: 69

Cited by: 2

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