ABCA1 acts as a protective modulator in amyotrophic lateral sclerosis
Year: 2025
Type: article
Abstract: = 0.006) and correlated with metabolic parameters (BMI and LDL). Spatiotemporal profiling confirmed ABCA1 upregulation in ALS patient blood and spinal cords, and progressive upregulation in ALS model mice. Collectively, we validated a diagnostic signature and identified ABCA1 as a protective, compensatory biomarker in ALS, emphasizing the link between metabolic adaptation and neurodegeneration.
Source: iScience
Authors: Qiang Li, Ge Zhang, Honglin Zheng, Taiqi Zhao, Hang Zhang, Yaochong Zhang, Haiyang Luo, Yuming Xu
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Awards: G1354353571, G286253239, G3728177002, G6735835
OpenAlex ID: W4416971849