Work

Therapeutic effect of daucosterol on DSS-induced colitis in mice

Year: 2025

Type: article

Abstract: Ulcerative colitis (UC) is an intestinal disease caused by multiple factors that severely affects the health of humans and animals. In this study, a DSS-induced mouse colitis model was utilized to investigate the ability of daucosterol (DAU) to alleviate colitis and its underlying mechanism of action. The experimental results showed that DAU could alleviate the clinical symptoms of colitis in mice, reduce the expression of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) in mouse serum, and modulate the gut microbiota to alleviate DSS-induced colitis in mice. In conclusion, DAU has great potential in the prevention of colitis.

Source: BMC Microbiology

DOI: 10.1186/s12866-025-04556-6

Authors: Jing Liang, Huihui Yang, Kelin Chen, Jiahao Cai, Yuling Wang, Yanhong Yong

Institution: Guangdong Ocean University

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990