Quantifying the link: coronary artery inflammation via CCTA-derived fat attenuation index and its association with diabetes duration
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aims: Although diabetes is a well-established enhancer of coronary inflammation, the specific relationship between diabetes duration and the degree of inflammation, as quantified by pericoronary fat attenuation index (FAI), remains poorly defined. This study aimed to investigate the association between diabetes duration and coronary inflammation, as assessed non-invasively by the pericoronary FAI derived from coronary computed tomography angiography (CCTA). Materials and methods: We enrolled 468 adults with type 2 diabetes mellitus who underwent CCTA imaging. The pericoronary FAI was quantified around the three main coronary arteries. Multivariablee association between diabetes duration and pericoronary FAI. Potential non-linear associations were examined using restricted cubic spline (RCS) modelling. Results: Longer diabetes duration was independently and positively associated with increased pericoronary FAI values in the LAD artery (β = 0.151, 95% CI: 0.064-0.238, P = 0.001), LCX artery (β = 0.101, 95% CI: 0.001-0.201, P = 0.047), and RCA (β = 0.208, 95% CI: 0.120-0.296, P < 0.001). RCS modelling revealed predominantly linear associations(P for non-linearity > 0.05). The association between diabetes duration and pericoronary FAI remained robust across the majority of examined subgroups. Conclusion: Prolonged diabetes duration is independently associated with elevated coronary inflammation, demonstrating a near-linear dose-response relationship.
Source: Frontiers in Endocrinology
Authors: Yan Zhang, Jing Wang, Kexin Song, Zhuhua Yao
Institutions: Nankai University, Tianjin Medical University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416975857