Synchronous angiomyolipoma with epithelial cysts and clear cell renal cell carcinoma: a case report
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Angiomyolipoma with Epithelial Cysts (AMLEC) is a rare renal tumor that has been established as a separate pathological entity in recent years. Existing literature has focused on its histological origin, molecular features, and imaging characteristics. To our knowledge, this is the first reported case of AMLEC coexisting with clear cell renal cell carcinoma (ccRCC). Case presentation: A 37-year-old male presented with lumbar pain and persistent gross hematuria. Imaging revealed tumor rupture with hemorrhage, initially suggestive of cystic renal cell carcinoma. However, postoperative pathology and immunohistochemistry confirmed a diagnosis of AMLEC combined with ccRCC. Conclusion: AMLEC is a rare subtype of angiomyolipoma (AML) that typically lacks adipose tissue, with an epithelial component likely derived from dilated renal tubules. Its unique histological features and immunohistochemical staining are key to pathological diagnosis. This report also reviews prior cases of AMLEC and synchronous renal tumors, offering a valuable reference for clinical diagnosis and management.
Source: Frontiers in Oncology
Authors: Jian Wang, Chengde Ren, Ziyang Qiang, Jintao Li, Hailin Ren, Guojun Chen, Xue Gong, Jiaxin Zhang
Institutions: Qinghai University, Qinghai University Affiliated Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Qinghai University
OpenAlex ID: W4416976010