Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Cancer is the second leading cause of death worldwide, and renal impairment frequently occurs during its course and treatment due to nephrotoxic chemotherapy and contrast exposure. Understanding baseline estimated glomerular filtration rate (eGFR) and its longitudinal changes in cancer patients is essential for effective kidney function management. Methods This multicenter study included 24,478 treatment-naïve cancer patients admitted to three cancer centers in 2018 and 61,883 non-cancer individuals undergoing health screening in the same year, with follow-up until 2023. eGFR was calculated using the CKD-EPI equation. Baseline eGFR and subsequent changes were compared between groups after stratification by age, sex, and comorbidity. Results Across all age groups, treatment-naïve cancer patients showed higher baseline eGFR values compared with non-cancer individuals of the same stratum (all p < 0.05). The median kidney volume was also larger in cancer patients (280 cm 3 vs. 271 cm 3 , p < 0.05). During the 5-year follow-up, cancer patients demonstrated a greater annual decline in eGFR than non-cancer individuals (all p < 0.01). Conclusion Treatment-naïve cancer patients exhibited higher baseline eGFR but a more pronounced subsequent decline compared with non-cancer individuals. These findings reflect observed associations rather than causal effects.
Source: Frontiers in Medicine
Authors: Baokui Ye, Xin Luo, Yunhan Luo, Zhaohui Zhou, Biao Jiang, Longbin Xiong, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Lihao Zhang, Xiaofeng Yang, Pei Dong, Yuying Liu, Yue Yan, Xiaohua Liu, Jiawei Xie, Yulong Xiao, Bokang Cui, Song Wang, Jinchang Lu, Zhiting He, Huiming Liu, Jing Li, Zhen Li, Wei Lu, Yancen Li, Haiying Liu, Tao Jia, Lizhi Niu, Fangjian Zhou, Chunping Yu, Zhiling Zhang
Institutions: Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Hunan Normal University, Hunan Provincial People's Hospital, Chenzhou First People's Hospital, Jinan University, Fuda Cancer Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416976029