Year: 2025
Type: article
Study design: Case Report
Abstract: The COVID-19 pandemic has significantly impacted global health since its emergence in late 2019. Established evidence indicates an increasing incidence of hematologic abnormalities caused by COVID-19, such as aplastic anemia. Only a few pediatric cases have been reported. We present a previously healthy 18-month-old boy with fever, cough, diarrhea, rash, and ear discharge for one week. He was febrile, tachycardic, drowsy, with bilateral purulent ear discharge, petechiae, and cervical lymphadenopathy. Blood tests showed severe pancytopenia with high inflammatory markers, and SARS-CoV-2 PCR was positive. Bone marrow biopsy revealed severe aplastic anemia (<10% cellularity), and genetic testing excluded inherited causes. He was treated with blood transfusions and romiplostim. After one year of supportive management, the patient showed a partial response and improving counts, so bone marrow transplantation was deferred, with continued monitoring for sustained hematologic recovery or relapse.
Source: Cureus
DOI: 10.7759/cureus.98419
Institutions: University of Sharjah, Alexandria University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416977006