Work

Analysis of the clinical value of combined monitoring of methylation transferase Wilms' tumour 1-associating protein and lipoprotein-associated phospholipase A2 in patients with coronary artery disease

Year: 2025

Type: article

Abstract: Objective: Clinical significance and correlation study of methyltransferase Wilms' tumour 1-associated protein (WTAP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with coronary artery disease (CAD). Methods: This study enrolled 282 symptomatic patients with suspected CAD. Serum biomarkers including lipids, inflammatory markers (CRP, Lp-PLA2), and WTAP mRNA levels (quantified via RT-PCR) were analyzed. Coronary severity was assessed using Gensini scores. Results: CAD patients exhibited significantly elevated WTAP expression and higher Lp-PLA2 levels. WTAP correlated strongly with Lp-PLA2, CRP, and Gensini scores. Multivariate analysis identified WTAP and Lp-PLA2 as independent CAD predictors. Combined WTAP/Lp-PLA2 detection demonstrated superior diagnostic performance (AUC = 0.9548, sensitivity = 95.26%, specificity = 90.16%). Conclusion: WTAP and Lp-PLA2 synergistically reflect CAD progression, offering dual biomarkers for risk stratification.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1540047

Authors: Fengxia Guo, Bing Hu, Gang Li

Institutions: Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou People's Hospital

Language: English

Topic: Lipoproteins and Cardiovascular Health

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801