Work

Surgical intervention strategies for tumor microenvironment (TME) associated therapeutic resistance

Year: 2025

Type: article

Abstract: The tumor microenvironment (TME) drives therapeutic resistance through immunosuppression, stromal remodeling, and metabolic reprogramming, which pose a major challenge in solid tumor treatment. While surgery remains a cornerstone for tumor eradication, perioperative inflammatory responses and ischemia-reperfusion injuries may exacerbate TME deterioration. However, surgery also offers a strategic opportunity for TME modulation. This narrative review analyzes TME components and resistance mechanisms, proposing a multi-stage intervention framework: preoperative TME reshaping, intraoperative precision resection with local therapy, and postoperative dynamic monitoring. We further explore a multidisciplinary whole-course management model, integrating cutting-edge technologies such as radiomics and single-cell sequencing. By bridging basic research with clinical translation, this review aims to guide surgeons in transitioning from tumor resection to TME precision regulation, with a focus on perioperative multi-stage interventions.

Source: Discover Oncology

DOI: 10.1007/s12672-025-04092-9

Authors: Dong Chen, Hanyu Wang, Xu Che

Institution: Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690