Work

Evolution of proteolysis-targeting chimeras (PROTAC) technology to overcome challenges of antimicrobial resistance

Year: 2025

Type: article

Abstract: Targeted protein degradation (TPD) is an innovative therapeutic approach that bypasses traditional drug inhibition methods. Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that harness degradation machinery to remove target proteins. This review examines the evolution of PROTACs and their application in targeting microorganisms that develop drug resistance, covering their development, advancements in linker design, E3 ligase selection, and delivery methods, including nanoparticles and exosomes.

Source: npj Antimicrobials and Resistance

DOI: 10.1038/s44259-025-00136-w

Authors: Dhanashree N. Sarwan, Pramod B. Khedekar, Ritesh P. Bhole, Rupesh V. Chikhale

Institutions: Rashtrasant Tukadoji Maharaj Nagpur University, UCL School of Pharmacy, University College London

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190