Exploring the selective inhibitory effects of Flavoxate and its analogues on two chloride channels and neuronal action potentials
Year: 2025
Type: article
Abstract: values of 32.8 μM, 28.3 μM, and 26.5 μM, respectively. These results suggest that Flavoxate is highly efficient and selective for VRAC inhibition, with the 8-substituent on its flavonoid core being crucial for this selectivity. All three flavonoids strongly inhibit AP firing, indicating that their core structure contributes to analgesic effects. In summary, Flavoxate is a selective VRAC inhibitor and a potential neuropathic pain inhibitor by suppressing AP firing in small DRG neurons.
DOI: 10.4196/kjpp.25.050
Authors: Gaohua Zhang, Anmin Zhou, Junjiang Liu, Jiping Wang, Jixia Yang, Yan Cui, Yingtong Zhao, Yaxin Song, Yunxia Li, Honglin Li, Xuan Zhang, Yuanyuan Zhang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4416978278
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