Year: 2025
Type: article
Abstract: Route-dependent effects of GM-CSF on systemic and mucosal myeloid activation in rhesus macaques. Subcutaneous GM-CSF administration induced rapid systemic expansion of myeloid cells, accompanied by chemokine release (MCP-1, CXCL13 and IL-1RA) and enrichment of Fc receptor-bearing myeloid populations (CD64+ and CD32+) in circulation. These cells subsequently migrated to rectal and vaginal mucosa along chemokine gradients, resulting in sustained mucosal infiltration without overt systemic inflammation. In contrast, topical mucosal GM-CSF delivery elicited no detectable systemic expansion, chemokine induction or myeloid recruitment. Figure made in ©BioRender—biorender.com.
Source: Immunology and Cell Biology
DOI: 10.1111/imcb.70069
Authors: Jingchen Zhou, Fernando Souza‐Fonseca‐Guimaraes
Institution: The University of Queensland
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G6522182991
OpenAlex ID: W4416979022