Figure 3 from SM08502-Mediated β-Catenin Repression Synergizes with Olaparib to Inhibit Tumor Progression
Year: 2025
Type: other
Abstract: SM08502 reduces HGSC tumor growth and attenuates TCF transcriptional activity in olaparib-resistant tumors. A, GFP-expressing PDX-GTFB1016-OR tumors in NSG mice treated with olaparib, SM08502, or in combination (ola + SM). PO, orally. B, Representative GFP images on day 28. C, Tumor volume at the time of necropsy. D, Volcano plot of genes in ola + SM compared with control. Red dots = adj. P < 0.05, FC > 1. Blue dots = adj. P < 0.05, FC < −1. E, Volcano plot of genes in ola + SM compared with olaparib. Red dots = adj. P < 0.05, FC > 1. Blue dots = adj. P < 0.05, FC < −1. F, Volcano plot of genes in ola + SM compared with SM08502 alone. Red dots = adj. P < 0.05, FC > 1. Blue dots = adj. P < 0.05, FC < −1. G, Heatmap of Reactome TCF-dependent signaling in response to WNT pathway (also see Supplementary Table S3). Error bars, SEM. Statistical test, one way ANOVA with Tukey multiple comparison correction (C), unpaired t test with Benjamini–Hochberg correction for adj. P value (D–F).
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4416979536
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