Rheology of physiological fluids and their artificial substitutes
Year: 2025
Type: article
Abstract: Biological fluids exhibit complex rheological behaviors that are essential for physiological function and significantly altered in disease. Direct studies of native fluids, however, are constrained by invasive sampling, variability, and limited reproducibility, underscoring the importance of developing mimicking fluids. Unlike early substitutes based on Newtonian solutions, next-generation mimicking systems aim to reproduce non-Newtonian features such as thixotropy, and pH-dependent transitions. Recent advances highlight multicomponent formulations and simulation frameworks that more faithfully capture the defining rheological signatures of biofluids, yet most approaches remain preliminary and rely on simplified or animal-derived components. This review synthesizes progress in mimicking systems for major biofluids, identifies current challenges including limited pathological data and lack of standardized protocols, and emphasizes the need for integrated experimental and computational strategies. Looking ahead, future efforts should combine microstructural characterization, standardized rheological databases, and AI-enhanced modeling with sustainable materials. Such developments will establish physiologically accurate and reproducible mimicking fluids, enabling broad applications in diagnostics, medical device testing, and precision medicine.
Source: Korea-Australia Rheology Journal
Authors: Jinhyeong Lee, Jiho Choi
Institutions: Hongik University, Soongsil University
Language: English
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,790
Award: G5746966847
OpenAlex ID: W4416981036