Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The frequent occurrence of respiratory diseases in the island reef environment of the navy severely affects the health of personnel and the combat effectiveness of the troops. Current common screening methods can only indicate whether there is an infection with pathogenic microorganisms but not the degree of disease progression. Therefore, it is necessary to identify simple-to-operate and cost-effective methods that indicate the degree of disease progression, based on traditional screening methods. AIM: To explores correlation between serum concentrations of nicotinamide phosphoribosyltransferase (NAMPT), nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), and the risk of upper respiratory infections in the island reef envirsonment. METHODS: A total of 600 cases of upper respiratory infections among naval officers and soldiers were included. Types of infection were confirmed through sputum culture combined with multiplex polymerase chain reaction. The serum concentrations of NAMPT and NMNAT1 were measured using ELISA, and infection severity was assessed using the pneumonia severity index (PSI). Statistical analysis was performed using nonparametric tests and Spearman correlation analysis. RESULTS: > 0.05). CONCLUSION: Concentrations of NAMPT and NMNAT1 are closely related to severity of upper respiratory infections, and their common regulatory mechanisms provide new directions for development of broad-spectrum anti-infection strategies.
Source: World Journal of Clinical Cases
Authors: Guo-Feng Gao, Jiao Yu, Sui-Yi Liu
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416983077