Performance evaluation of different filtration fraction during continuous renal replacement therapy
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: OBJECTIVES: To investigate the effects of different filtration fractions (FFs) during continuous venovenous hemodiafiltration (CVVHDF) post-dilution. METHODS: This study employed a single-blind, head-to-head randomized controlled design. Patients who underwent daytime continuous renal replacement therapy (CRRT) in the Department of Nephrology, the Second Affiliated Hospital of Nanchang University between April 2022 and June 2023 were prospectively enrolled. They were randomly assigned to either a low FF group (FF set at 20%-<25%) or a high FF group (FF set at 25%-30%). All patients received post-dilution CVVHDF with systemic heparin anticoagulation. The primary outcome was extracorporeal circuit coagulation, comprehensively assessed through dynamic monitoring of arterial pressure, venous pressure, and transmembrane pressure, combined with filter clotting grading at the end of the session. Secondary outcomes included changes in serum creatinine, urea, potassium, and pH levels before and after treatment to evaluate efficacy. RESULTS: >0.05). CONCLUSIONS: For patients with a relatively short treatment duration of 10-12 h undergoing post-dilution CVVHDF, employing an FF of 25%-30% does not pose a higher risk of extracorporeal circuit coagulation compared to an FF of 20%-<25%, but shows higher creatinine clearance.
Authors: Li WANG, Yanxia CHEN, Gaosi XU, Chengyun XU
Institution: Second Affiliated Hospital of Nanchang University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Nanchang University
OpenAlex ID: W4416983225