Work

Synergizing biomaterials and cellular molecular pathways: a new frontier in hair follicle generation

Year: 2025

Type: article

Abstract: Despite significant advances in our understanding of hair follicle cycling and regeneration, creating fully functional hair follicles with active cycling capabilities remains a considerable challenge for clinical applications. This literature review aims to explore the molecular and cellular mechanisms that govern hair follicle development and cycling, highlighting key signaling pathways involved in these processes. We also discuss biomaterials and emerging regenerative strategies that show promise for biofabricating hair follicles. Specifically, we summarize current research on innovative techniques such as hair micropatterning models, hair follicle organoids, three-dimensional printing of microneedle arrays, microfollicle generation, and biofabrication technologies. This review emphasizes the necessity of a multifaceted approach that integrates stem cell research and tissue engineering technologies to optimize hair follicle regeneration and enhance therapeutic outcomes.

Source: Journal of Translational Medicine

DOI: 10.1186/s12967-025-07211-w

Authors: Amir Bajouri, Nasser Aghdami, Mohammad Ali Nilforoushzadeh

Institutions: Tehran University of Medical Sciences, Royan Institute, Academic Center for Education, Culture and Research

Language: English

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890