Work

A rare case of adult H3 K27-altered diffuse midline glioma with multifocal cerebrospinal fluid disseminated disease

Year: 2025

Type: article

Abstract: H3 K27-altered diffuse midline gliomas are a group of highly aggressive glial brain tumors that occur predominantly in children and carry a poor prognosis with limited treatment options. These are most often found in the thalamus, brainstem, or spinal cord. We report a case of a 28-year-old male with 1-month history of headache who was found to have multiple lesions involving the brainstem, cerebellum, pineal gland, and suprasellar region. On magnetic resonance imaging, the lesions demonstrated mild T2/FLAIR hyperintensity, T1 hypo- to isointensity, and rim contrast enhancement with central necrosis. Subtle diffusion restriction was noted across the lesions. Histopathological analysis following stereotactic biopsy confirmed the diagnosis of H3 K27-altered diffuse midline glioma.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.11.042

Authors: Jackie Chen, Samuel Conyngham, Angela Bayly, Jacqueline McMaster, Jason Trang

Institution: Westmead Hospital

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600