Work

Circulating microRNAs in post myocardial infarction remodeling: toward precision cardiology

Year: 2025

Type: article

Abstract: Post-myocardial infarction (MI) ventricular remodeling is a major cause of heart failure, despite advances in revascularization and pharmacotherapy. Circulating microRNAs (miRNAs) are emerging as biomarkers for risk stratification and therapeutic targeting. This letter reviews their role in apoptosis, inflammation, and fibrosis, highlights studies from Europe, Asia, and North America, and discusses technological advances, including exosome-based miRNA panels and machine learning models. Limitations include analytical variability, limited geographic representation, and lack of integration into clinical care. Recommendations include standardizing methods, conducting large international studies, and developing actionable miRNA algorithms. Integrating miRNA profiling into post-MI care has the potential to improve risk assessment, personalize therapy, and reduce the burden of heart failure.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000004468

Authors: Muhammad Khizar, Muhammad Zaib, Muhammad Bilal, Hasibullah Aminpoor, Hasiba Karimi

Institutions: Georgian American University, Shahida Islam Medical and Dental, Kabul University of Medical Sciences Abu Ali Ibn Sina, Bezmiâlem Vakıf Üniversitesi

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850