Band-Pass Raman Spectroscopy Unlocks Compact Point-of-Care Noninvasive Continuous Glucose Monitoring
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Noninvasive blood glucose monitoring with precision comparable to standard invasive or minimally invasive methods has been a long-sought goal, especially as diabetes rates soar, with 592 million cases worldwide expected by 2035. Various optical and spectroscopic technologies have challenged noninvasive continuous glucose monitoring (CGM), but most methods fail to detect physiological levels or lack miniaturization for practical use. Based on our previous success in direct observation of glucose signals from in vivo skin, we developed a band-pass Raman spectroscopy method that enables noninvasive, physiological-level CGM in a compact device. Using off-axis 830 nm near-infrared illumination and intraspectrum reference, we eliminate most elastically scattered photons, revealing the glucose Raman signal through an amplified photodetector, while compensating for background variations. Our approach, validated on both tissue phantoms and in vivo human skin, overcomes bulky spectrometers and makes portable Raman-based CGM devices a reality.
Source: Analytical Chemistry
Institution: Massachusetts Institute of Technology
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: National Cancer Center, National Institutes of Health, Korea Technology and Information Promotion Agency for SMEs, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences
OpenAlex ID: W4416986463