Year: 2025
Type: article
Abstract: Gadolinium-neutron capture therapy (Gd-NCT) employs Gadolinium (Gd) isotopes and thermal neutrons to specifically target and kill cancer at cells level. This study investigates the targeting efficacy of 157 Gd-DOTA-HK (DHK), a novel agent designed for Gd-NCT and MRI. We synthesized 157 Gd-DHK, which combines a Gd-DOTA complex as a neutron capturer and MRI probe with αvβ6 binding peptide (HK) for targeted Pancreas adenocarcinoma (PDAC) therapy. 157 Gd-DHK demonstrated a significantly high binding affinity for BxPC-3 cells. scintigraphy revealed that the optimal time window for Gd-NCT was 26 h after injection. The conjugate’s imaging capabilities and its potential as an MRI contrast agent were validated. The conjugate effectively triggered nuclear reactions via Gd-NCT, leading to efficient tumor cell destruction. Photon sensitization studies showed that 157 Gd-DHK induced photon-mediated phototoxicity in cancer cells while exhibiting minimal toxicity. 157 Gd-DHK shows great potential as a theranostic agent for targeted imaging of PDAC and Gd-NCT applications. It presents a novel strategy to enhance the specificity and efficacy of Gd-NCT in cancer treatment.
Authors: Liang Xie, Cuiping Song, Jialin Qin, Qianqian Xu, Jianchun Yin, Yuanyuan Ma, Hong Chen, Chao Li, Bing Hong, Ni Chen, Xiaoxi Pang
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,390
Award: G6832523315
OpenAlex ID: W4416988616