Work

Synthesis of S - or N -glycomimetics of d -galactono-1,4-lactone: inhibitors of a β-galactofuranosidase

Year: 2025

Type: article

Abstract: sp. JHA19 ORF 1110 demonstrated that the lactam is also a potential inhibitor of this enzyme. Inhibition of β-galactofuranosidases may serve as a novel chemotherapeutic approach for treating human pathogens that contain galactofuranosyl structures, such as those responsible for leprosy and tuberculosis.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob01674f

Authors: Walter E. Jara, Carla Marino, Linda Toro Melgarejo, Oscar Varela, Evangelina Repetto

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires