Work

Engineering tunable GTP/TPi-responsive liposomes through liposomal membrane modulation using a bis-triphenylphosphonium lipid switch

Year: 2025

Type: article

Abstract: Liposomes incorporating a bis-phosphonium lipid switch exhibit tunable cargo release triggered by GTP or TPi. Modulating lipid ratios within the liposome controls metabolite selectivity and release kinetics for responsive cargo delivery.

Source: RSC Pharmaceutics

DOI: 10.1039/d5pm00206k

Authors: Brooke E. Smith, Caleb G. Russell, Mayesha B. Mustafa, Michael D. Best

Institution: University of Tennessee at Knoxville

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: diamond

Funders: National Science Foundation, Division of Materials Research

Awards: Graduate Research Fellowship Program (GRFP), G218092134, Synthetic Lipid Switches for Controlling Liposome Assembly and Release, G633452075

OpenAlex ID: W4416993092

FWCI: 0.188

Cites: 30

Cited by: 1

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