Work

Bladder Washing Cytology in the Detection of High-Grade Prostatic Adenocarcinoma: A Case Report

Year: 2025

Type: article

Abstract: Bladder washing cytology is a valuable diagnostic tool primarily used in the evaluation of urothelial malignancies. However, its role in detecting metastatic or secondary malignancies, such as high-grade prostatic adenocarcinoma, is less commonly recognized. We present the case of an 82-year-old man whose post-cystoscopy bladder washing cytology revealed atypical glandular cells. Immunocytochemical staining showed strong NKX3.1 nuclear positivity, suggesting a prostatic origin. Subsequent transurethral resection of the prostate confirmed high-grade prostatic adenocarcinoma with intraductal carcinoma and a cribriform growth pattern, classified as International Society of Urological Pathology (ISUP) Grade Group 4 (Gleason score 4+4=8). Notably, NKX3.1-positive malignant cells were also identified in a follow-up voided urine sample. This case underscores the potential utility of urine cytology, particularly when supplemented by immunocytochemistry, in the diagnosis of prostate cancer.

Source: Cureus

DOI: 10.7759/cureus.98444

Authors: Gabriel Pastrana, Camille L Santiago Negron, Suheidy Cardona, Juan C Santa Rosario, María D Rivera Rolón

Institutions: University of Medicine and Health Sciences, University of Puerto Rico, Medical Sciences Campus, University of Puerto Rico System

Language: English

Topic: Prostate Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416993467