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Invasive pneumococcal disease presenting with abdominal pain, vomiting and diarrhoea in a patient with multiple myeloma

Year: 2025

Type: article

Abstract: Background: is a leading cause of community-acquired pneumonia and meningitis, but intra-abdominal manifestations are rare, particularly in adults without underlying peritoneal disease. Primary pneumococcal peritonitis is classically associated with cirrhosis, nephrotic syndrome, or peritoneal dialysis, and has seldom been reported in patients with haematological malignancies. Multiple myeloma significantly increases the risk of invasive pneumococcal disease due to impaired humoral immunity and hypogammaglobulinemia. Case report: , confirming atypical invasive pneumococcal disease manifesting as spontaneous primary peritonitis with secondary enterocolitis. Despite broad-spectrum antibiotics, the patient developed persistent sepsis complicated by multiple intra-abdominal abscesses. Echocardiography and a spine CT scan excluded endocarditis or vertebral involvement. Source control was achieved through three ultrasound-guided percutaneous drainage procedures, resulting in gradual clinical and radiological resolution. She was discharged on day 42 with complete recovery and scheduled pneumococcal vaccination. Conclusion: This case highlights a rare and severe gastrointestinal manifestation of invasive pneumococcal disease in a high-risk host. Spontaneous pneumococcal peritonitis complicated by multiple intra-abdominal abscesses is exceptionally uncommon in multiple myeloma. Early recognition, multidisciplinary management, and minimally invasive source control were crucial to a favourable outcome. Preventive strategies, particularly pneumococcal vaccination, remain essential to reduce morbidity in immunocompromised patients. LEARNING POINTS: Atypical invasive pneumococcal disease involving the peritoneum and gastrointestinal tract is rare in adults, but immunocompromised patients, such as those with multiple myeloma, are at increased risk of morbidity and mortality.Timely, targeted antibiotic therapy combined with effective source control through image-guided drainage of intra-abdominal abscesses is crucial for recovery and minimizes the need for surgery.Prompt recognition, integrated multidisciplinary management, and vaccination are essential to improve outcomes and prevent recurrence in vulnerable patients.

Source: European Journal of Case Reports in Internal Medicine

DOI: 10.12890/2025_005890